An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase.
Chem Commun (Camb)
; 56(3): 399-402, 2020 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-31820751
ABSTRACT
A combinatorial approach using a one-bead-one-compound method and a screening based on a SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effects when cells were subjected to oxidative stress.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Materiales Biocompatibles
/
Cobre
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article