Hyperreflective foci in predicting the treatment outcome of antivascular endothelial growth factor in neovascular age-related macular degeneration.
Graefes Arch Clin Exp Ophthalmol
; 258(2): 273-280, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-31828425
ABSTRACT
PURPOSE:
To describe the optical coherence tomographic findings of hyperreflective foci (HF) in neovascular age-related macular degeneration and evaluate the use of HF to predict visual outcome after antivascular endothelium growth factor (anti-VEGF) therapy.METHODS:
This was a post-hoc analysis of a retrospective cohort study. Hyperreflective foci were localized in the inner retina, outer retina, or subretinal fluid (SRF) layer. The treatment response of HF was recorded. The association between HF and visual outcome was analyzed.RESULTS:
We enrolled 126 eyes. Hyperreflective foci involving more than one layer were associated with poor initial visual acuity (P < 0.001). Hyperreflective foci in each layer at baseline were negatively correlated with baseline visual acuity. At 3 months posttreatment, HF in the SRF layer had decreased significantly (P = 0.003), which was faster compared with HF in other layers. Baseline HF status at each layer was not associated with final visual outcome. The eyes with reduced HF in the SRF at 3 months had better visual improvement at 12 months (P = 0.038).CONCLUSION:
Hyperreflective foci involving multiple layers were associated with poor initial visual acuity but not with final visual outcome. With anti-VEGF treatment, HF in the SRF layer resolved faster, which may predict better visual outcome.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Refracción Ocular
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Proteínas Recombinantes de Fusión
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Agudeza Visual
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Receptores de Factores de Crecimiento Endotelial Vascular
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Tomografía de Coherencia Óptica
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Degeneración Macular Húmeda
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Ranibizumab
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Mácula Lútea
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Año:
2020
Tipo del documento:
Article