Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules.

Wang, Ziqiang; Li, Kun; Chen, Wei; Wang, Xiaoxia; Huang, Yikun; Wang, Weiming; Wu, Wanjun; Cai, Zhiming; Huang, Weiren

Wang, Ziqiang; Li, Kun; Chen, Wei; Wang, Xiaoxia; Huang, Yikun; Wang, Weiming; Wu, Wanjun; Cai, Zhiming; Huang, Weiren.

Wang Z; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.
Li K; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Chen W; Department of Nuclear Medicine, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, 250014, China.
Wang X; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.
Huang Y; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Wang W; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.
Wu W; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Cai Z; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.
Huang W; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.

Cell Mol Life Sci ; 77(17): 3441-3452, 2020 Sep.

Article en En | MEDLINE | ID: mdl-31838573

Asunto(s)

Epigénesis Genética; Linfocitos Infiltrantes de Tumor/metabolismo; Factores de Empalme Serina-Arginina/metabolismo; Linfocitos T CD8-positivos/citología; Linfocitos T CD8-positivos/inmunología; Linfocitos T CD8-positivos/metabolismo; Antígeno CTLA-4/genética; Antígeno CTLA-4/metabolismo; Carcinoma de Células Renales/metabolismo; Carcinoma de Células Renales/patología; Histonas/metabolismo; Humanos; Interferón gamma/metabolismo; Células Jurkat; Neoplasias Renales/metabolismo; Neoplasias Renales/patología; Linfocitos Infiltrantes de Tumor/citología; Linfocitos Infiltrantes de Tumor/inmunología; Regiones Promotoras Genéticas; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Factor de Transcripción STAT3/metabolismo; Factores de Empalme Serina-Arginina/antagonistas & inhibidores; Factores de Empalme Serina-Arginina/genética; Microambiente Tumoral; Factores de Transcripción p300-CBP/metabolismo

Palabras clave

Epigenetic regulation; Histone modification; Immune checkpoint; SRSF2; T-cell exhaustion

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos Infiltrantes de Tumor / Epigénesis Genética / Factores de Empalme Serina-Arginina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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