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Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.
Perusina Lanfranca, Mirna; Zhang, Yaqing; Girgis, Alexander; Kasselman, Samantha; Lazarus, Jenny; Kryczek, Illona; Delrosario, Lawrence; Rhim, Andrew; Koneva, Lada; Sartor, Maureen; Sun, Lei; Halbrook, Christopher; Nathan, Hari; Shi, Jiaqi; Crawford, Howard C; Pasca di Magliano, Marina; Zou, Weiping; Frankel, Timothy L.
  • Perusina Lanfranca M; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Zhang Y; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Girgis A; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Kasselman S; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Lazarus J; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Kryczek I; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Department of Pathology, University of Michigan, Ann Arbor, Michigan.
  • Delrosario L; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Rhim A; Department of Gastroenterology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Koneva L; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan.
  • Sartor M; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan.
  • Sun L; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Halbrook C; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Nathan H; Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • Shi J; Department of Pathology, University of Michigan, Ann Arbor, Michigan.
  • Crawford HC; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Pasca di Magliano M; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan; Program in Cellular and Molecular Biology,
  • Zou W; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Department of Pathology, University of Michigan, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan; Graduate Programs in Immunology and Tumor Biology, University of Michigan, Ann Arbor, Michigan.
  • Frankel TL; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. Electronic address: timofran@med.umich.edu.
Gastroenterology ; 158(5): 1417-1432.e11, 2020 04.
Article en En | MEDLINE | ID: mdl-31843590
Asunto(s)
Células Acinares/patología; Carcinoma Ductal Pancreático/inmunología; Transformación Celular Neoplásica/inmunología; Interleucinas/metabolismo; Neoplasias Pancreáticas/inmunología; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/inmunología; Células Acinares/inmunología; Animales; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/mortalidad; Carcinoma Ductal Pancreático/patología; Línea Celular Tumoral/trasplante; Plasticidad de la Célula/efectos de los fármacos; Plasticidad de la Célula/inmunología; Transformación Celular Neoplásica/efectos de los fármacos; Modelos Animales de Enfermedad; Transición Epitelial-Mesenquimal/efectos de los fármacos; Transición Epitelial-Mesenquimal/inmunología; Femenino; Células HEK293; Humanos; Interleucinas/inmunología; Quinasas Janus/antagonistas & inhibidores; Quinasas Janus/metabolismo; Masculino; Metaplasia/inmunología; Metaplasia/patología; Ratones; Ratones Noqueados; Nitrilos; Páncreas/citología; Páncreas/inmunología; Páncreas/patología; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/mortalidad; Neoplasias Pancreáticas/patología; Pancreatitis/inmunología; Pancreatitis/patología; Pirazoles/farmacología; Piridonas/farmacología; Pirimidinas; Pirimidinonas/farmacología; ARN Interferente Pequeño/metabolismo; Receptores de Interleucina/metabolismo; Factor de Transcripción STAT3/antagonistas & inhibidores; Transducción de Señal/efectos de los fármacos; Análisis de Supervivencia; Interleucina-22
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Transformación Celular Neoplásica / Interleucinas / Carcinoma Ductal Pancreático / Factor de Transcripción STAT3 / Células Acinares Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Transformación Celular Neoplásica / Interleucinas / Carcinoma Ductal Pancreático / Factor de Transcripción STAT3 / Células Acinares Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article