Differences in medical treatment and clinical characteristics between men and women with heart failure - a single-centre multivariable analysis.
Eur J Clin Pharmacol
; 76(4): 539-546, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-31897534
ABSTRACT
PURPOSE:
The aims of this study were to examine sex differences in a heart failure population with regards to treatment and patient characteristics and to investigate the impact of sex on achieved doses of heart failure medications. METHODS ANDRESULTS:
A total of 1924 patients with heart failure in a regional hospital were analysed, 622 patients had ejection fraction ≤ 40% of which 30% were women. In patients with reduced ejection fraction, women were older (79 ± 11 vs. 74 ± 12 years, P < 0.001), had lower body weight (70 ± 17 vs. 86 ± 18 kg, P < 0.001), lower estimated glomerular filtration rate (eGFR) (49 ± 24 vs. 71 ± 30 ml/min, P < 0.001) and received lower doses of heart failure medications than men. Multivariable linear regression on patients with reduced ejection fraction showed that sex was not associated with achieved dose of any heart failure medication. For angiotensin-converting enzyme inhibitors and angiotensin receptor blockers associated factors were eGFR, systolic blood pressure, age, ejection fraction, and heart rate. For beta-blockers associated factors were body weight, atrial fibrillation and age. For mineralocorticoid receptor antagonists associated factors were eGFR, serum potassium, age, systolic blood pressure, ejection fraction and heart rate.CONCLUSION:
Women with heart failure and reduced ejection fraction were prescribed lower doses of heart failure medications, were older, had worse renal function, and lower body weight than men. Sex was not independently associated with achieved doses of heart failure medications, instead age, renal function and body weight explained the differences in treatment.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Volumen Sistólico
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Inhibidores de la Enzima Convertidora de Angiotensina
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Caracteres Sexuales
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Antagonistas Adrenérgicos beta
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Antagonistas de Receptores de Angiotensina
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Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article