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The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.
Aimé, Pascaline; Karuppagounder, Saravanan S; Rao, Apeksha; Chen, Yingxin; Burke, Robert E; Ratan, Rajiv R; Greene, Lloyd A.
  • Aimé P; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, 650 W. 168(th) Street, New York, NY 10032, USA; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 650 W. 168(th) Street, New York,
  • Karuppagounder SS; Burke Neurological Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, 407 E. 61st Street, New York, NY 10065, USA.
  • Rao A; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, 650 W. 168(th) Street, New York, NY 10032, USA.
  • Chen Y; Burke Neurological Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, 407 E. 61st Street, New York, NY 10065, USA.
  • Burke RE; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, 650 W. 168(th) Street, New York, NY 10032, USA; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, 650 W. 168(th) Street, Ne
  • Ratan RR; Burke Neurological Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, 407 E. 61st Street, New York, NY 10065, USA.
  • Greene LA; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, 650 W. 168(th) Street, New York, NY 10032, USA; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 650 W. 168(th) Street, New York,
Neurobiol Dis ; 136: 104725, 2020 03.
Article en En | MEDLINE | ID: mdl-31911115
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Quinolinas / Proteínas de Ciclo Celular / Trastornos Parkinsonianos / Factor de Transcripción Activador 4 / Factor de Transcripción CHOP Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Quinolinas / Proteínas de Ciclo Celular / Trastornos Parkinsonianos / Factor de Transcripción Activador 4 / Factor de Transcripción CHOP Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article