Novel metrics to measure the effect of additive inputs on the activity of sensory system neurons.

ABSTRACT

Sensory systems, such as the visual or auditory system, are highly non linear. It is therefore not easy to predict the effect of additive inputs on the spiking activity of related brain structures. Here, we propose two metrics to study the effect of additive covariates on the spiking activity of neurons. These metrics are directly obtained from a generalized linear model. We apply these metrics to the study of the effect of additive input audio noise on the spiking activity of neurons in the auditory system. To do so, we combine clean vocalisations with natural stationary or non-stationary noises and record activity in the auditory system while presenting the noisy vocalisations. We found that non-stationary noise has a greater effect on the neural activity than stationary noise. We observe that the results, obtained using the proposed metrics, is more consistent with current knowledge in auditory neuroscience than the results obtained when using a common metric from the literature, the extraction index.