Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.

Zhang, Yali; Chen, Hongjin; Zhang, Wenxin; Cai, Yan; Shan, Peiren; Wu, Di; Zhang, Bing; Liu, Hui; Khan, Zia A; Liang, Guang

Zhang, Yali; Chen, Hongjin; Zhang, Wenxin; Cai, Yan; Shan, Peiren; Wu, Di; Zhang, Bing; Liu, Hui; Khan, Zia A; Liang, Guang.

Zhang Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China.
Chen H; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Zhang W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Cai Y; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Shan P; Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325025, China.
Wu D; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhang B; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China.
Liu H; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Khan ZA; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 32560

Biochim Biophys Acta Mol Basis Dis ; 1866(5): 165683, 2020 05 01.

Article en En | MEDLINE | ID: mdl-31953218

Asunto(s)

Lesión Pulmonar Aguda/tratamiento farmacológico; Ácido Araquidónico/farmacología; Miocarditis/tratamiento farmacológico; Obesidad/complicaciones; Sepsis/tratamiento farmacológico; Transducción de Señal/efectos de los fármacos; Lesión Pulmonar Aguda/inmunología; Animales; Ácido Araquidónico/uso terapéutico; Línea Celular; Dieta Alta en Grasa/efectos adversos; Modelos Animales de Enfermedad; Ácidos Grasos/inmunología; Ácidos Grasos/metabolismo; Humanos; Lipopolisacáridos/inmunología; Pulmón/inmunología; Pulmón/patología; Antígeno 96 de los Linfocitos/antagonistas & inhibidores; Antígeno 96 de los Linfocitos/metabolismo; Macrófagos/efectos de los fármacos; Macrófagos/inmunología; Macrófagos/metabolismo; Masculino; Ratones; Miocarditis/inmunología; Miocarditis/patología; Miocardio/inmunología; Miocardio/patología; Miocitos Cardíacos; Obesidad/inmunología; Obesidad/metabolismo; Ácido Palmítico/toxicidad; Cultivo Primario de Células; Ratas; Sepsis/inmunología; Transducción de Señal/inmunología; Receptor Toll-Like 4/metabolismo

Palabras clave

Arachidonic acid; Inflammation; Lipopolysaccharide; Myeloid differentiation factor 2; Saturated fatty acids; Toll-like receptor-4

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Ácido Araquidónico / Sepsis / Lesión Pulmonar Aguda / Miocarditis / Obesidad Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article

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