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Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes.
Sarwar, Md Shahid; Xia, Yi-Xuan; Liang, Zheng-Ming; Tsang, Siu Wai; Zhang, Hong-Jie.
  • Sarwar MS; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
  • Xia YX; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.
  • Liang ZM; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
  • Tsang SW; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
  • Zhang HJ; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Biomolecules ; 10(1)2020 01 16.
Article en En | MEDLINE | ID: mdl-31963204
ABSTRACT
Since the first discovery in 1961, more than 1300 ent-kaurane diterpenoids have been isolated and identified from different plant sources, mainly the genus Isodon. Chemically, they consist of a perhydrophenanthrene subunit and a cyclopentane ring. A large number of reports describe the anticancer potential and mechanism of action of ent-kaurane compounds in a series of cancer cell lines. Oridonin is one of the prime anticancer ent-kaurane diterpenoids that is currently in a phase-I clinical trial in China. In this review, we have extensively summarized the anticancer activities of ent-kaurane diterpenoids according to their plant sources, mechanistic pathways, and biological targets. Literature analysis found that anticancer effect of ent-kauranes are mainly mediated through regulation of apoptosis, cell cycle arrest, autophagy, and metastasis. Induction of apoptosis is associated with modulation of BCL-2, BAX, PARP, cytochrome c, and cleaved caspase-3, -8, and -9, while cell cycle arrest is controlled by cyclin D1, c-Myc, p21, p53, and CDK-2 and -4. The most common metastatic target proteins of ent-kauranes are MMP-2, MMP-9, VEGF, and VEGFR whereas LC-II and mTOR are key regulators to induce autophagy.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diterpenos de Tipo Kaurano / Neoplasias / Antineoplásicos Fitogénicos Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diterpenos de Tipo Kaurano / Neoplasias / Antineoplásicos Fitogénicos Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article