CXCR2-modified CAR-T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma.

Liu, Guangna; Rui, Wei; Zheng, Hongli; Huang, Daosheng; Yu, Fei; Zhang, Yuewei; Dong, Jiahong; Zhao, Xueqiang; Lin, Xin

CXCR2-modified CAR-T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma.

Liu, Guangna; Rui, Wei; Zheng, Hongli; Huang, Daosheng; Yu, Fei; Zhang, Yuewei; Dong, Jiahong; Zhao, Xueqiang; Lin, Xin.

Liu G; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.
Rui W; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.
Zheng H; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.
Huang D; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.
Yu F; Center of Hepatopancreatobiliary Diseases, Beijing Tsinghua Changgung Hospital, Tsinghua University, School of Medicine, Beijing, China.
Zhang Y; Center of Hepatopancreatobiliary Diseases, Beijing Tsinghua Changgung Hospital, Tsinghua University, School of Medicine, Beijing, China.
Dong J; Center of Hepatopancreatobiliary Diseases, Beijing Tsinghua Changgung Hospital, Tsinghua University, School of Medicine, Beijing, China.
Zhao X; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.
Lin X; Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China.

Eur J Immunol ; 50(5): 712-724, 2020 05.

Article en En | MEDLINE | ID: mdl-31981231

Asunto(s)

Carcinoma Hepatocelular/terapia; Inmunoterapia Adoptiva/métodos; Neoplasias Hepáticas/terapia; Receptores Quiméricos de Antígenos/genética; Receptores de Interleucina-8B/genética; Linfocitos T Citotóxicos/inmunología; Animales; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/inmunología; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Movimiento Celular; Quimiocina CCL2/genética; Quimiocina CCL2/inmunología; Quimiocina CXCL5/genética; Quimiocina CXCL5/inmunología; Citotoxicidad Inmunológica; Expresión Génica; Humanos; Interleucina-8/genética; Interleucina-8/inmunología; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/inmunología; Neoplasias Hepáticas/patología; Ratones; Receptores Quiméricos de Antígenos/inmunología; Receptores de Interleucina-8B/inmunología; Linfocitos T Citotóxicos/citología; Carga Tumoral; Microambiente Tumoral/inmunología; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CAR-T; CXCR2; Chemokine; Immunotherapy

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Inmunoterapia Adoptiva / Carcinoma Hepatocelular / Receptores de Interleucina-8B / Receptores Quiméricos de Antígenos / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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