Therapeutic Germline Editing: Sense and Sensibility.

Adashi, Eli Y; Cohen, I Glenn

Adashi, Eli Y; Cohen, I Glenn.

Adashi EY; Warren Alpert Medical School, Brown University, Providence, RI, USA. Electronic address: eli_adashi@brown.edu.
Cohen IG; Harvard Law School, Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard University, Cambridge, MA, USA.

Trends Genet ; 36(5): 315-317, 2020 05.

Article en En | MEDLINE | ID: mdl-31982142

ABSTRACT

ABSTRACT

Safe and effective heritable editing of the human genome is years away from the clinic because of formidable technical, statutory, regulatory, and societal challenges. In particular, we note the fledgling state of the science, the imperatives of editing efficiency, specificity, and uniformity, and the extant legal roadblock.

Asunto(s)

Sistemas CRISPR-Cas/genética; Edición Génica/tendencias; Genoma Humano/genética; Mutación de Línea Germinal/genética; Humanos

Palabras clave

CRISPR/Cas9; editing; embryo; genome; heritable

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Humano / Mutación de Línea Germinal / Sistemas CRISPR-Cas / Edición Génica Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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