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Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
Gonatopoulos-Pournatzis, Thomas; Niibori, Rieko; Salter, Eric W; Weatheritt, Robert J; Tsang, Brian; Farhangmehr, Shaghayegh; Liang, Xinyi; Braunschweig, Ulrich; Roth, Jonathan; Zhang, Shen; Henderson, Tyler; Sharma, Eesha; Quesnel-Vallières, Mathieu; Permanyer, Jon; Maier, Stefan; Georgiou, John; Irimia, Manuel; Sonenberg, Nahum; Forman-Kay, Julie D; Gingras, Anne-Claude; Collingridge, Graham L; Woodin, Melanie A; Cordes, Sabine P; Blencowe, Benjamin J.
  • Gonatopoulos-Pournatzis T; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: t.gonatopoulos@gmail.com.
  • Niibori R; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Salter EW; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Weatheritt RJ; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; EMBL Australia, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.
  • Tsang B; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Farhangmehr S; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Liang X; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
  • Braunschweig U; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
  • Roth J; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Zhang S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Henderson T; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Sharma E; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Quesnel-Vallières M; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Permanyer J; Centre for Genomic Regulation, Barcelona 08003, Spain.
  • Maier S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Georgiou J; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Irimia M; Centre for Genomic Regulation, Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain; ICREA, Barcelona 08010, Spain.
  • Sonenberg N; Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Forman-Kay JD; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Collingridge GL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Woodin MA; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
  • Cordes SP; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: cordes@lunenfeld.ca.
  • Blencowe BJ; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: b.blencowe@utoronto.ca.
Mol Cell ; 77(6): 1176-1192.e16, 2020 03 19.
Article en En | MEDLINE | ID: mdl-31999954
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Exones / Factor 4G Eucariótico de Iniciación / Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil / Disfunción Cognitiva / Neuroblastoma / Neuronas Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Exones / Factor 4G Eucariótico de Iniciación / Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil / Disfunción Cognitiva / Neuroblastoma / Neuronas Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article