Apremilast for the treatment of hidradenitis suppurativa associated with psoriatic arthritis in multimorbid patients: Case report and review of literature.
Medicine (Baltimore)
; 99(5): e18991, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-32000436
ABSTRACT
INTRODUCTION:
Hidradenitis suppurativa is a complex, chronic, difficult to treat condition belonging to the spectrum of cutaneous immune-mediated inflammatory diseases. Systemic treatment options for moderate-severe disease are limited to TNF-alpha antagonists and other biologic agents, with limited clinical evidence. PATIENT CONCERNS We report two adult patients with severe hidradenitis suppurativa presenting concomitant psoriatic arthritis and multiple medical comorbidities. Both were ineligible or resistant to adalimumab, the only biologic drug approved for the treatment of hidradenitis. DIAGNOSIS Both patients were diagnosed with severe Hurley III-stage disease and psoriatic arthritis, showing resistance to first-line systemic treatments and a complex comorbidity profile.INTERVENTIONS:
Patients underwent treatment with apremilast, an oral phosphodiesterase-4 inhibitor, approved for the treatment of psoriatic arthritis.OUTCOMES:
After 16 weeks of treatment, a clinically relevant improvement of inflammatory lesions, skin- and arthritis-related pain, and patient-reported outcomes was achieved in both patients. Apremilast was well tolerated and continued up to 48 weeks of treatment.CONCLUSION:
We report the "real-life" use of apremilast in the treatment of multimorbid patients with hidradenitis suppurativa and review its potential role in the management of this severe condition.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Talidomida
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Artritis Psoriásica
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Antiinflamatorios no Esteroideos
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Hidradenitis Supurativa
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article