Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease.

Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn Inge; Sandvik, Arne Kristian; Bruland, Torunn

Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn Inge; Sandvik, Arne Kristian; Bruland, Torunn.

Østvik AE; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Svendsen TD; Department of G2astroenterology and Hepatology, Clinic of Medicine, St. Olav's University Hospital, Trondheim, Norway.
Granlund AVB; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Doseth B; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Skovdahl HK; Centre of Molecular Inflammation Research, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Bakke I; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Thorsvik S; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Afroz W; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Walaas GA; Clinic of Medicine, St Olav's University Hospital, Trondheim, Norway.
Mollnes TE; Clinic of Laboratory Medicine, St. Olav's University Hospital, Trondheim, Norway.
Gustafsson BI; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Sandvik AK; Department of G2astroenterology and Hepatology, Clinic of Medicine, St. Olav's University Hospital, Trondheim, Norway.
Bruland T; Centre of Molecular Inflammation Research, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.

J Crohns Colitis ; 14(7): 920-934, 2020 Jul 30.

Article en En | MEDLINE | ID: mdl-32020185

Asunto(s)

Colitis Ulcerosa/inmunología; Enfermedad de Crohn/inmunología; Citocinas/metabolismo; Células Epiteliales/inmunología; Células Epiteliales/metabolismo; Interferón Tipo I/genética; Ubiquitinas/metabolismo; Biopsia; Antígeno CD11a/genética; Colitis Ulcerosa/genética; Colitis Ulcerosa/metabolismo; Colitis Ulcerosa/patología; Colon/metabolismo; Colon/patología; Enfermedad de Crohn/genética; Enfermedad de Crohn/metabolismo; Enfermedad de Crohn/patología; Citocinas/genética; Citocinas/farmacología; Expresión Génica/efectos de los fármacos; Células HT29; Humanos; Inmunidad Innata; Interferón Tipo I/metabolismo; Interleucina-12/farmacología; Janus Quinasa 1/genética; Janus Quinasa 1/metabolismo; Leucocitos Mononucleares/inmunología; Leucocitos Mononucleares/metabolismo; Antígeno-1 Asociado a Función de Linfocito/metabolismo; Organoides/metabolismo; ARN Mensajero/metabolismo; Receptores de Reconocimiento de Patrones; Factores de Transcripción STAT/genética; Factores de Transcripción STAT/metabolismo; Análisis de Secuencia de ARN; Transducción de Señal/efectos de los fármacos; Receptor Toll-Like 3; Factor de Necrosis Tumoral alfa/farmacología; Ubiquitinas/genética; Ubiquitinas/farmacología; Regulación hacia Arriba

Palabras clave

Human intestinal organoids; ISG15; innate immunity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitinas / Colitis Ulcerosa / Enfermedad de Crohn / Interferón Tipo I / Citocinas / Células Epiteliales Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article

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