Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy.

Tubita, Alessandro; Lombardi, Zoe; Tusa, Ignazia; Dello Sbarba, Persio; Rovida, Elisabetta

Tubita, Alessandro; Lombardi, Zoe; Tusa, Ignazia; Dello Sbarba, Persio; Rovida, Elisabetta.

Tubita A; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Lombardi Z; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Tusa I; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Dello Sbarba P; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Rovida E; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.

Int J Mol Sci ; 21(3)2020 Jan 31.

Article en En | MEDLINE | ID: mdl-32023850

Asunto(s)

Núcleo Celular/metabolismo; Citoplasma/metabolismo; Proteína Quinasa 7 Activada por Mitógenos/metabolismo; Neoplasias/metabolismo; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Terapia Molecular Dirigida; Neoplasias/tratamiento farmacológico; Transporte de Proteínas

Palabras clave

BMK1; MAPK; MAPK7; SUMOylation; alternative kinase targeting; chaperones; nuclear localization; nuclear signaling; protein phosphorylation; ubiquitination

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Núcleo Celular / Citoplasma / Proteína Quinasa 7 Activada por Mitógenos / Neoplasias Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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