Allosteric regulation of menaquinone (vitamin K<sub>2</sub>) biosynthesis in the human pathogen <i>Mycobacterium tuberculosis</i>.

Bashiri, Ghader; Nigon, Laura V; Jirgis, Ehab N M; Ho, Ngoc Anh Thu; Stanborough, Tamsyn; Dawes, Stephanie S; Baker, Edward N; Bulloch, Esther M M; Johnston, Jodie M

Allosteric regulation of menaquinone (vitamin K₂) biosynthesis in the human pathogen Mycobacterium tuberculosis.

Bashiri, Ghader; Nigon, Laura V; Jirgis, Ehab N M; Ho, Ngoc Anh Thu; Stanborough, Tamsyn; Dawes, Stephanie S; Baker, Edward N; Bulloch, Esther M M; Johnston, Jodie M.

Bashiri G; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Nigon LV; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Jirgis ENM; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Ho NAT; School of Physical and Chemical Sciences, Biomolecular Interaction Centre (BIC), and Maurice Wilkins Centre for Molecular Biodiscovery, University of Canterbury, Christchurch 8041, New Zealand.
Stanborough T; School of Physical and Chemical Sciences, Biomolecular Interaction Centre (BIC), and Maurice Wilkins Centre for Molecular Biodiscovery, University of Canterbury, Christchurch 8041, New Zealand.
Dawes SS; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Baker EN; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Bulloch EMM; Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Johnston JM; School of Physical and Chemical Sciences, Biomolecular Interaction Centre (BIC), and Maurice Wilkins Centre for Molecular Biodiscovery, University of Canterbury, Christchurch 8041, New Zealand jodie.johnston@canterbury.ac.nz.

J Biol Chem ; 295(12): 3759-3770, 2020 03 20.

Article en En | MEDLINE | ID: mdl-32029475

Asunto(s)

Proteínas Bacterianas/metabolismo; Mycobacterium tuberculosis/metabolismo; Vitamina K 2/metabolismo; Regulación Alostérica/efectos de los fármacos; Sitio Alostérico; Secuencia de Aminoácidos; Proteínas Bacterianas/antagonistas & inhibidores; Proteínas Bacterianas/genética; Sitios de Unión; Biocatálisis; Dominio Catalítico; Cristalografía por Rayos X; Humanos; Mutagénesis Sitio-Dirigida; Mycobacterium tuberculosis/enzimología; Naftoles/química; Naftoles/metabolismo; Naftoles/farmacología; Conformación Proteica; Proteínas Recombinantes/biosíntesis; Proteínas Recombinantes/química; Proteínas Recombinantes/aislamiento & purificación; Alineación de Secuencia

Palabras clave

Mycobacterium tuberculosis; SEPHCHC synthase (MenD); allosteric regulation; allostery; cooperativity; feedback inhibition, 1,4-dihydroxy-2-naphthoic acid (DHNA); menaquinone (vitamin K2) biosynthesis, drug target; pyruvate oxidase (POX) enzymes; structural biology; thiamine diphosphate (ThDP)-dependent enzymes; vitamin K

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Vitamina K 2 / Mycobacterium tuberculosis Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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