Sister chromatid exchange and chromosome abnormalities in uremic patients.

Cengiz, K; Block, A M; Hossfeld, D K; Anthone, R; Anthone, S; Sandberg, A A

Cengiz, K; Block, A M; Hossfeld, D K; Anthone, R; Anthone, S; Sandberg, A A.

Cengiz K; Roswell Park Memorial Institute, Buffalo General Hospital, New York.

Cancer Genet Cytogenet ; 36(1): 55-67, 1988 Nov.

Article en En | MEDLINE | ID: mdl-3203298

ABSTRACT

ABSTRACT

Chronic renal failure heightens the risk of malignancy. We therefore examined lymphocytes from 44 uremic patients and 24 normal controls for chromosome abnormalities and sister chromatid exchange (SCE) rate. This is the first report of SCE in uremia. Uremia was found to increase structurally abnormal chromosomes and elevate the rate of SCE. These cytogenetic changes in uremia may play a role in the heightened risk of cancer.

Asunto(s)

Aberraciones Cromosómicas; Intercambio de Cromátides Hermanas; Uremia/genética; Adulto; Anciano; Femenino; Humanos; Cariotipificación; Linfocitos/ultraestructura; Masculino; Persona de Mediana Edad; Neoplasias/etiología; Factores de Riesgo; Uremia/complicaciones

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Banco de datos: MEDLINE Asunto principal: Intercambio de Cromátides Hermanas / Uremia / Aberraciones Cromosómicas Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 1988 Tipo del documento: Article

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