Recent advances in understanding the hepatotoxicity associated with protein kinase inhibitors.

Shi, Qiang; Yang, Xi; Ren, Lijun; Mattes, William B

Shi, Qiang; Yang, Xi; Ren, Lijun; Mattes, William B.

Shi Q; Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.
Yang X; Division of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Ren L; Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.
Mattes WB; Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.

Expert Opin Drug Metab Toxicol ; 16(3): 217-226, 2020 Mar.

Article en En | MEDLINE | ID: mdl-32050817

Asunto(s)

Enfermedad Hepática Inducida por Sustancias y Drogas/diagnóstico; Hepatocitos/efectos de los fármacos; Hígado/efectos de los fármacos; Inhibidores de Proteínas Quinasas/efectos adversos; Animales; Enfermedad Hepática Inducida por Sustancias y Drogas/enzimología; Hepatocitos/enzimología; Humanos; Hígado/enzimología; Inhibidores de Proteínas Quinasas/farmacocinética

Palabras clave

Boxed warnings; drug induced liver injury; hepatocytes; hepatotoxicity; mitochondria; protein kinase inhibitors; regorafenib

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepatocitos / Inhibidores de Proteínas Quinasas / Enfermedad Hepática Inducida por Sustancias y Drogas / Hígado Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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