CT-based internal density calibration for opportunistic skeletal assessment using abdominal CT scans.
Med Eng Phys
; 78: 55-63, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-32059948
ABSTRACT
CT-based opportunistic skeletal assessment complements current osteoporosis diagnosis. Quantitative assessment by internal density calibration overcomes the limitations of phantom-based calibration. We sought to establish and validate an internal calibration technique using abdominal CT scans and establish reproducibility precision for three density calibration techniques. Ten full-body cadavers were CT scanned at the spine and pelvis with a calibration phantom. Internal calibration was performed using in-scan tissue references and deriving a voxel-specific calibration. Bone mineral density (BMD) and finite element (FE) failure load assessed skeletal health. Three independent users measured intra-exam precision by manual tissue selection. To verify results, ten subjects were imaged using an abdominal imaging protocol. Internal calibration performed equivalently to gold-standard phantom-based calibration in the cadaver spine and hip. Internal calibration BMD precision in the spine was 7 mg/cc (4.9%) and FE precision was 163 N (7.2%), whereas phantom-based precision was 3 mg/cc (1.8%) and 77 N (3.8%). Internal calibration hip BMD and FE precision was 11 mg/cc (5.3%) and 84 N (6.0%), whereas phantom-based precision was 2 mg/cc (1.3%) and 30 N (3.4%). Using the abdominal imaging protocol, internal calibration performed comparably to phantom-based calibration. Internal calibration provides BMD and FE outcome precision within 7.2% for opportunistic skeletal health assessment.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Columna Vertebral
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Tomografía Computarizada por Rayos X
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Densidad Ósea
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Abdomen
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Cadera
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Aged80
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Female
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Humans
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Male
Idioma:
En
Año:
2020
Tipo del documento:
Article