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A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance.
Langenhorst, Jurgen B; Boss, Jill; van Kesteren, Charlotte; Lalmohamed, Arief; Kuball, Jürgen; Egberts, Antoine C G; Boelens, Jaap Jan; Huitema, Alwin D R; van Maarseveen, Erik M.
  • Langenhorst JB; Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Boss J; Model-informed Drug Development Consultant, Pharmetheus AB, Uppsala, Sweden.
  • van Kesteren C; Hospital Pharmacy, St Jansdal Hospital, Harderwijk, The Netherlands.
  • Lalmohamed A; Hospital Pharmacy, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
  • Kuball J; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Egberts ACG; Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Boelens JJ; Department of Hematology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Huitema ADR; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
  • van Maarseveen EM; Department of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Br J Clin Pharmacol ; 86(8): 1499-1509, 2020 08.
Article en En | MEDLINE | ID: mdl-32067250

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Busulfano / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Busulfano / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article