RPI-SE: a stacking ensemble learning framework for ncRNA-protein interactions prediction using sequence information.
BMC Bioinformatics
; 21(1): 60, 2020 Feb 18.
Article
en En
| MEDLINE
| ID: mdl-32070279
ABSTRACT
BACKGROUND:
The interactions between non-coding RNAs (ncRNA) and proteins play an essential role in many biological processes. Several high-throughput experimental methods have been applied to detect ncRNA-protein interactions. However, these methods are time-consuming and expensive. Accurate and efficient computational methods can assist and accelerate the study of ncRNA-protein interactions.RESULTS:
In this work, we develop a stacking ensemble computational framework, RPI-SE, for effectively predicting ncRNA-protein interactions. More specifically, to fully exploit protein and RNA sequence feature, Position Weight Matrix combined with Legendre Moments is applied to obtain protein evolutionary information. Meanwhile, k-mer sparse matrix is employed to extract efficient feature of ncRNA sequences. Finally, an ensemble learning framework integrated different types of base classifier is developed to predict ncRNA-protein interactions using these discriminative features. The accuracy and robustness of RPI-SE was evaluated on three benchmark data sets under five-fold cross-validation and compared with other state-of-the-art methods.CONCLUSIONS:
The results demonstrate that RPI-SE is competent for ncRNA-protein interactions prediction task with high accuracy and robustness. It's anticipated that this work can provide a computational prediction tool to advance ncRNA-protein interactions related biomedical research.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al ARN
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Análisis de Secuencia de ARN
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Análisis de Secuencia de Proteína
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ARN no Traducido
Tipo de estudio:
Evaluation_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Año:
2020
Tipo del documento:
Article