HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.

Chen, Chao; Sun, Ming-An; Warzecha, Claude; Bachu, Mahesh; Dey, Anup; Wu, Tiyun; Adams, Peter D; Macfarlan, Todd; Love, Paul; Ozato, Keiko

Chen, Chao; Sun, Ming-An; Warzecha, Claude; Bachu, Mahesh; Dey, Anup; Wu, Tiyun; Adams, Peter D; Macfarlan, Todd; Love, Paul; Ozato, Keiko.

Chen C; Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Sun MA; Mammalian Epigenome Reprogramming Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Warzecha C; Hematopoiesis and Lymphocyte Biology Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Bachu M; Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Dey A; Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Wu T; Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Adams PD; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Macfarlan T; Mammalian Epigenome Reprogramming Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Love P; Hematopoiesis and Lymphocyte Biology Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Ozato K; Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ozatok@nih.gov.

Cell Rep ; 30(7): 2136-2149.e4, 2020 02 18.

Article en En | MEDLINE | ID: mdl-32075733

Asunto(s)

Proteínas de Ciclo Celular/metabolismo; Cromatina/metabolismo; Síndrome de DiGeorge/genética; Chaperonas de Histonas/metabolismo; Factores de Transcripción/metabolismo; Animales; Proteínas de Ciclo Celular/genética; Cromatina/genética; Síndrome de DiGeorge/metabolismo; Femenino; Hematopoyesis/fisiología; Células Madre Hematopoyéticas/citología; Células Madre Hematopoyéticas/metabolismo; Chaperonas de Histonas/genética; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Factores de Transcripción/genética

Palabras clave

DiGeorge syndrome; H3.3; HIRA; hematopoietic stem cells; histone chaperone

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Cromatina / Proteínas de Ciclo Celular / Síndrome de DiGeorge / Chaperonas de Histonas Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

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