CUX1 and I&#954;BÎ¶ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.

Slowikowski, Kamil; Nguyen, Hung N; Noss, Erika H; Simmons, Daimon P; Mizoguchi, Fumitaka; Watts, Gerald F M; Gurish, Michael F; Brenner, Michael B; Raychaudhuri, Soumya

CUX1 and IκBÎ¶ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.

Slowikowski, Kamil; Nguyen, Hung N; Noss, Erika H; Simmons, Daimon P; Mizoguchi, Fumitaka; Watts, Gerald F M; Gurish, Michael F; Brenner, Michael B; Raychaudhuri, Soumya.

Slowikowski K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Nguyen HN; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Noss EH; Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Simmons DP; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.
Mizoguchi F; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115.
Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Gurish MF; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Raychaudhuri S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Proc Natl Acad Sci U S A ; 117(10): 5532-5541, 2020 03 10.

Article en En | MEDLINE | ID: mdl-32079724

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales/metabolismo; Artritis Reumatoide/metabolismo; Fibroblastos/metabolismo; Proteínas de Homeodominio/metabolismo; Inflamación/metabolismo; Interleucina-17/fisiología; Proteínas Represoras/metabolismo; Factores de Transcripción/metabolismo; Transcriptoma/fisiología; Factor de Necrosis Tumoral alfa/fisiología; Proteínas Adaptadoras Transductoras de Señales/genética; Artritis Reumatoide/genética; Células Cultivadas; Quimiocina CXCL1/genética; Quimiocina CXCL2/genética; Quimiocinas CXC/genética; Factores Quimiotácticos/genética; Fibroblastos/efectos de los fármacos; Proteínas de Homeodominio/genética; Humanos; Inflamación/genética; Interleucina-17/farmacología; Interleucina-6/genética; Metaloproteinasa 3 de la Matriz/metabolismo; Monocitos/efectos de los fármacos; Monocitos/fisiología; ARN Interferente Pequeño/genética; Proteínas Represoras/genética; Células del Estroma/efectos de los fármacos; Células del Estroma/metabolismo; Líquido Sinovial; Factor de Transcripción ReIA/metabolismo; Factores de Transcripción/genética; Transcriptoma/efectos de la radiación; Factor de Necrosis Tumoral alfa/farmacología

Palabras clave

RNA-seq; inflammation; regulation; time series; transcription

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Proteínas Represoras / Factores de Transcripción / Factor de Necrosis Tumoral alfa / Proteínas de Homeodominio / Interleucina-17 / Proteínas Adaptadoras Transductoras de Señales / Transcriptoma / Fibroblastos / Inflamación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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