A micellized fluorescence sensor based on amplified quenching for highly sensitive detection of non-transferrin-bound iron in serum.

ABSTRACT

A novel, micelle-based fluorescence system capable of selective and sensitive signal transduction for non-transferrin-bound iron (NTBI) in serum was devised. We demonstrated that an aggregated fluorogenic core in a micelle induces amplified fluorescence quenching, which differentiates this sensing platform from the numerous fluorescence-based tools previously developed for sensitive detection.