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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Andreano, Kaitlyn J; Wardell, Suzanne E; Baker, Jennifer G; Desautels, Taylor K; Baldi, Robert; Chao, Christina A; Heetderks, Kendall A; Bae, Yeeun; Xiong, Rui; Tonetti, Debra A; Gutgesell, Lauren M; Zhao, Jiong; Sorrentino, Jessica A; Thompson, Delita A; Bisi, John E; Strum, Jay C; Thatcher, Gregory R J; Norris, John D.
  • Andreano KJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Baker JG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Desautels TK; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Baldi R; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Chao CA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Heetderks KA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Bae Y; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA.
  • Xiong R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (M/C 781), Chicago, IL, 60612, USA.
  • Tonetti DA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (M/C 781), Chicago, IL, 60612, USA.
  • Gutgesell LM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (M/C 781), Chicago, IL, 60612, USA.
  • Zhao J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (M/C 781), Chicago, IL, 60612, USA.
  • Sorrentino JA; G1 Therapeutics, Inc, 700 Park Offices Drive, Suite 200, Research Triangle Park, NC, 27709, USA.
  • Thompson DA; G1 Therapeutics, Inc, 700 Park Offices Drive, Suite 200, Research Triangle Park, NC, 27709, USA.
  • Bisi JE; G1 Therapeutics, Inc, 700 Park Offices Drive, Suite 200, Research Triangle Park, NC, 27709, USA.
  • Strum JC; G1 Therapeutics, Inc, 700 Park Offices Drive, Suite 200, Research Triangle Park, NC, 27709, USA.
  • Thatcher GRJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (M/C 781), Chicago, IL, 60612, USA.
  • Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 308 Research Drive, Durham, NC, 27710, USA. jdn001@duke.edu.
Breast Cancer Res Treat ; 180(3): 635-646, 2020 Apr.
Article en En | MEDLINE | ID: mdl-32130619
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Anticuerpos Anti-VIH / Moduladores Selectivos de los Receptores de Estrógeno / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Anticuerpos Monoclonales Humanizados / Neoplasias Hormono-Dependientes Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Anticuerpos Anti-VIH / Moduladores Selectivos de los Receptores de Estrógeno / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Anticuerpos Monoclonales Humanizados / Neoplasias Hormono-Dependientes Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2020 Tipo del documento: Article