[GG Genotype at rs1275988 and rs2586886 Loci of TWIK-related Acid-sensitive K + Channel-1 Gene is A Potential Risk Factor for Severe Obstructive Sleep Apnea].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 42(1): 16-23, 2020 Feb 28.
Article
en Zh
| MEDLINE
| ID: mdl-32131935
ABSTRACT
Objective To explore the mechanism of obstructive sleep apnea(OSA) by assessing the association between human TWIK-related acid-sensitive K + channel-1(TASK-1) gene and OSA. Methods A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region,China,from April to December 2016.Two single nucleotide polymorphisms(rs1275988 and rs2586886) in the TASK-1 gene were selected and genotyped using a Kompetitive Allele Specific PCR genotyping system. Results In patients with blood potassium <3.95 mmol/L,the distribution of rs1275988 alleles(G vs.A)(χ 2=4.474,P=0.034) and recessive model(GG+GA vs.AA)(χ 2=4.327,P=0.038) showed significant differences between severe and non-OSA groups.The distribution of rs2586886 alleles(G vs.A)(χ 2=6.345,P=0.012) and dominant model(AA+GA vs.GA)(χ 2=4.431,P=0.035) showed significant differences between severe and non-OSA groups.The Logistic regression analysis showed that the GG genotype was a risk factor for OSA patients with blood potassium <3.95 mmol/L(OR=7.854,95% CI1.710-36.000,P=0.008;OR=8.849,95% CI1.816-43.117,P=0.007). Conclusions Both the GG genotypes of rs1275988 and rs2586886 in the TASK-1 gene may be potential risk factors in severe OSA patients with blood potassium <3.95 mmol/L.Serum potassium>3.95 mmol/L in patients with TASK-1 GG genotype may be conducive to reducing the incidence of severe OSA.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apnea Obstructiva del Sueño
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Canales de Potasio de Dominio Poro en Tándem
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Proteínas del Tejido Nervioso
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
País como asunto:
Asia
Idioma:
Zh
Año:
2020
Tipo del documento:
Article