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Tuberculosis in pregnant women and neonates: A meta-review of current evidence.
K J, Snow; A, Bekker; G K, Huang; S M, Graham.
  • K J S; Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia; Centre for Adolescent Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia;
  • A B; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
  • G K H; The Burnet Institute, Melbourne, Australia.
  • S M G; Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia; The Burnet Institute, Melbourne, Australia; International Union Against Tuberculosis and Lung Disease (The Union), Par
Paediatr Respir Rev ; 36: 27-32, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32144052
ABSTRACT
Pregnant women and their infants are a vulnerable but neglected population in tuberculosis (TB) control efforts. Recent advances in TB prevention, diagnosis and treatment have implications for their care, despite their frequent exclusion from research. We have conducted a meta-review of current evidence and clinical guidelines for TB prevention, diagnosis and management in pregnant women and neonates, focusing on review articles published since 2010. The actual burden of TB in pregnancy is unmeasured, but has been estimated at 216,500 cases per year. Although the effect of pregnancy on TB risk is uncertain and controversial, two large whole-of-population studies found that pregnancy was associated with a two- to three-fold increase in risk of TB. Congenital TB is rare but extremely serious. Neonates exposed to TB after delivery will be at high risk of disease, and preventive therapy is recommended once disease has been ruled out. At present, there is limited evidence regarding the performance of different screening strategies for pregnant women, appropriate drug dosing for either pregnant women or neonates, and the safety of most second-line drugs in pregnancy. High quality evidence on these topics is needed, as are detailed guidelines to inform efforts by TB control programs and clinicians working with pregnant women and their infants.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Tuberculosis Pulmonar / Enfermedades del Recién Nacido Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Female / Humans / Newborn / Pregnancy Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Tuberculosis Pulmonar / Enfermedades del Recién Nacido Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Female / Humans / Newborn / Pregnancy Idioma: En Año: 2020 Tipo del documento: Article