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The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping.
Zwanenburg, Alex; Vallières, Martin; Abdalah, Mahmoud A; Aerts, Hugo J W L; Andrearczyk, Vincent; Apte, Aditya; Ashrafinia, Saeed; Bakas, Spyridon; Beukinga, Roelof J; Boellaard, Ronald; Bogowicz, Marta; Boldrini, Luca; Buvat, Irène; Cook, Gary J R; Davatzikos, Christos; Depeursinge, Adrien; Desseroit, Marie-Charlotte; Dinapoli, Nicola; Dinh, Cuong Viet; Echegaray, Sebastian; El Naqa, Issam; Fedorov, Andriy Y; Gatta, Roberto; Gillies, Robert J; Goh, Vicky; Götz, Michael; Guckenberger, Matthias; Ha, Sung Min; Hatt, Mathieu; Isensee, Fabian; Lambin, Philippe; Leger, Stefan; Leijenaar, Ralph T H; Lenkowicz, Jacopo; Lippert, Fiona; Losnegård, Are; Maier-Hein, Klaus H; Morin, Olivier; Müller, Henning; Napel, Sandy; Nioche, Christophe; Orlhac, Fanny; Pati, Sarthak; Pfaehler, Elisabeth A G; Rahmim, Arman; Rao, Arvind U K; Scherer, Jonas; Siddique, Muhammad Musib; Sijtsema, Nanna M; Socarras Fernandez, Jairo.
  • Zwanenburg A; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Vallières M; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Abdalah MA; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Aerts HJWL; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Andrearczyk V; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Apte A; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Ashrafinia S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Bakas S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Beukinga RJ; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Boellaard R; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Bogowicz M; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Boldrini L; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Buvat I; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Cook GJR; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Davatzikos C; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Depeursinge A; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Desseroit MC; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Dinapoli N; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Dinh CV; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Echegaray S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • El Naqa I; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Fedorov AY; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Gatta R; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Gillies RJ; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Goh V; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Götz M; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Guckenberger M; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Ha SM; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Hatt M; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Isensee F; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Lambin P; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Leger S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Leijenaar RTH; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Lenkowicz J; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Lippert F; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Losnegård A; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Maier-Hein KH; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Morin O; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Müller H; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Napel S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Nioche C; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Orlhac F; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Pati S; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Pfaehler EAG; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Rahmim A; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Rao AUK; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Scherer J; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Siddique MM; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Sijtsema NM; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
  • Socarras Fernandez J; From OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, PF 41, 01307 Dresden, Germany (A.Z., S. Leger, E.G.C.T., C.R., S. Löck); National Cent
Radiology ; 295(2): 328-338, 2020 05.
Article en En | MEDLINE | ID: mdl-32154773
ABSTRACT
Background Radiomic features may quantify characteristics present in medical imaging. However, the lack of standardized definitions and validated reference values have hampered clinical use. Purpose To standardize a set of 174 radiomic features. Materials and Methods Radiomic features were assessed in three phases. In phase I, 487 features were derived from the basic set of 174 features. Twenty-five research teams with unique radiomics software implementations computed feature values directly from a digital phantom, without any additional image processing. In phase II, 15 teams computed values for 1347 derived features using a CT image of a patient with lung cancer and predefined image processing configurations. In both phases, consensus among the teams on the validity of tentative reference values was measured through the frequency of the modal value and classified as follows less than three matches, weak; three to five matches, moderate; six to nine matches, strong; 10 or more matches, very strong. In the final phase (phase III), a public data set of multimodality images (CT, fluorine 18 fluorodeoxyglucose PET, and T1-weighted MRI) from 51 patients with soft-tissue sarcoma was used to prospectively assess reproducibility of standardized features. Results Consensus on reference values was initially weak for 232 of 302 features (76.8%) at phase I and 703 of 1075 features (65.4%) at phase II. At the final iteration, weak consensus remained for only two of 487 features (0.4%) at phase I and 19 of 1347 features (1.4%) at phase II. Strong or better consensus was achieved for 463 of 487 features (95.1%) at phase I and 1220 of 1347 features (90.6%) at phase II. Overall, 169 of 174 features were standardized in the first two phases. In the final validation phase (phase III), most of the 169 standardized features could be excellently reproduced (166 with CT; 164 with PET; and 164 with MRI). Conclusion A set of 169 radiomics features was standardized, which enabled verification and calibration of different radiomics software. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Kuhl and Truhn in this issue.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Programas Informáticos / Biomarcadores Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Programas Informáticos / Biomarcadores Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article