STRIPAK Is a Regulatory Hub Initiating Hippo Signaling.
Trends Biochem Sci
; 45(4): 280-283, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-32169174
ABSTRACT
Signaling modules that integrate the diverse extra- and intracellular inputs to the Hippo pathway were previously unknown. By biochemical and molecular interrogation, Chen et al. established a molecular framework, the RhoA-RHPN-NF2/Kibra-STRIPAK axis, that regulates the status of Hippo core kinases and connects upstream signals to initiate and orchestrate the Hippo pathway.
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