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FSH signaling is involved in affective disorders.
Bi, Wen-Kai; Luan, Si-Si; Wang, Jing; Wu, Shan-Shan; Jin, Xin-Chen; Fu, Yi-Lin; Gao, Ling; Zhao, Jia-Jun; He, Zhao.
  • Bi WK; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Luan SS; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Wang J; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Wu SS; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Jin XC; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Fu YL; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Gao L; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • Zhao JJ; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
  • He Z; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicin
Biochem Biophys Res Commun ; 525(4): 915-920, 2020 05 14.
Article en En | MEDLINE | ID: mdl-32171529
ABSTRACT
Affective disorders are a set of mental disorders and particularly disrupt the mental health of susceptible women during puberty, pregnancy, parturition and menopause transition, which are characterized by dramatic changes in reproductive hormone profiles. The serum FSH level changes significantly during these periods; yet, the role of FSH in mood regulation is poorly understood. In the current study, FSHR knockout (Fshr-/-) mice displayed enhanced affective disorder behaviors in an open field test and a forced swim test, accompanied by altered gene expression profiles. The differentially expressed genes between Fshr-/- mice and Fshr+/+ mice were enriched in multiple neuroendocrine metabolic pathways. FSHR deletion significantly increased/decreased the mRNA and/or protein expression levels of AOX1, RDH12, HTR3a and HTR4 in mood-mediating brain regions, including the hippocampus and prefrontal cortex. These results reveal that FSH signaling is involved in the development of affective disorders.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de HFE / Corteza Prefrontal / Trastornos del Humor / Hormona Folículo Estimulante / Hipocampo Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de HFE / Corteza Prefrontal / Trastornos del Humor / Hormona Folículo Estimulante / Hipocampo Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article