PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes.

Jiang, Xu-Shun; Chen, Xue-Mei; Hua, Wei; He, Jun-Ling; Liu, Ting; Li, Xun-Jia; Wan, Jiang-Min; Gan, Hua; Du, Xiao-Gang

Jiang, Xu-Shun; Chen, Xue-Mei; Hua, Wei; He, Jun-Ling; Liu, Ting; Li, Xun-Jia; Wan, Jiang-Min; Gan, Hua; Du, Xiao-Gang.

Jiang XS; Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.
Chen XM; Emergency Department, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.
Hua W; Department of Nephrology, Occupational Disease Prevention and Control Hospital of Chongqing, Chongqing, China.
He JL; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Liu T; Department of Nephrology, Chengdu Fifth People's Hospital, Chengdu, 611130, China.
Li XJ; Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.
Wan JM; Department of Nephrology, Chongqing Qijiang People's Hospital, Tuowai, Chongqing, 401420, China.
Gan H; Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.
Du XG; Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing,

Biochem Biophys Res Commun ; 525(4): 954-961, 2020 05 14.

Article en En | MEDLINE | ID: mdl-32173525

Asunto(s)

Apoptosis/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Mitofagia/genética; Ácido Palmítico/farmacología; Podocitos/efectos de los fármacos; Proteínas Quinasas/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Animales; Apoptosis/genética; Autofagia/efectos de los fármacos; Autofagia/genética; Dieta Alta en Grasa; Silenciador del Gen; Riñón/metabolismo; Riñón/fisiopatología; Masculino; Potencial de la Membrana Mitocondrial/fisiología; Microscopía Electrónica de Transmisión; Proteínas Asociadas a Microtúbulos/metabolismo; Mitocondrias/metabolismo; Mitocondrias/ultraestructura; Obesidad/metabolismo; Podocitos/metabolismo; Podocitos/ultraestructura; Proteínas Quinasas/genética; Ratas; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Transducción de Señal/genética; Ubiquitina-Proteína Ligasas/genética

Palabras clave

Apoptosis; Mitophagy; PINK1/Parkin; Palmitic acid; Podocytes

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas / Apoptosis / Ácido Palmítico / Ubiquitina-Proteína Ligasas / Podocitos / Mitofagia / Mitocondrias Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

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