Caesalpanins A-C, Three Dimeric Cassane Diterpenoids from the Seeds of Caesalpinia sappan L.
Chem Biodivers
; 17(5): e2000103, 2020 May.
Article
en En
| MEDLINE
| ID: mdl-32180346
ABSTRACT
Three dimeric cassane diterpenoids, caesalpanins A-C, were isolated from the seeds of Caesalpinia sappan L., as well as three known compounds. Their structures were determined via analysis of 1D-, 2D-NMR, and HR-ESI-MS data. Caesalpanins A and B were the second and third compounds that presented a nitrogen-containing cassane diterpenoid dimer linked through one ether bond between C-19 and C-20'. Caesalpanin B exhibited moderate cytotoxic activity against MCF-7â
cell lines with IC50 value of 29.98â
µm. Caesalpanins A and B had weak inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 50â
µm with inhibitory rate of 36.01 % and 32.93 %, respectively.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Semillas
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Caesalpinia
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Diterpenos
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Antineoplásicos Fitogénicos
Límite:
Animals
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article