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Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats.
Asano, Ryutaro; Hosokawa, Katsuhiro; Taki, Shintaro; Konno, Shota; Shimomura, Ippei; Ogata, Hiromi; Okada, Mai; Arai, Kyoko; Onitsuka, Masayoshi; Omasa, Takeshi; Nakanishi, Takeshi; Umetsu, Mitsuo; Kumagai, Izumi.
  • Asano R; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan. ryutaroa@cc.tuat.ac.jp.
  • Hosokawa K; Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, 184-8588, Japan. ryutaroa@cc.tuat.ac.jp.
  • Taki S; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Konno S; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Shimomura I; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Ogata H; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Okada M; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Arai K; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Onitsuka M; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Omasa T; Institute of Technology and Science, Tokushima University, Tokushima, 770-8506, Japan.
  • Nakanishi T; Institute of Technology and Science, Tokushima University, Tokushima, 770-8506, Japan.
  • Umetsu M; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
  • Kumagai I; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
Sci Rep ; 10(1): 4913, 2020 03 18.
Article en En | MEDLINE | ID: mdl-32188928
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complejo CD3 / Anticuerpos Biespecíficos / Antineoplásicos Inmunológicos / Mutación Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complejo CD3 / Anticuerpos Biespecíficos / Antineoplásicos Inmunológicos / Mutación Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article