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A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR.
Cleary, James M; Calvo, Emiliano; Moreno, Victor; Juric, Dejan; Shapiro, Geoffrey I; Vanderwal, Carol Ann; Hu, Beibei; Gifford, Maryella; Barch, David; Roberts-Rapp, Lisa; Ansell, Peter J; Xiong, Hao; Ocampo, Christopher; Tolcher, Anthony W.
  • Cleary JM; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. JCLEARY@PARTNERS.ORG.
  • Calvo E; START Madrid-CIOCC, Madrid, Spain.
  • Moreno V; START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain.
  • Juric D; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
  • Shapiro GI; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
  • Vanderwal CA; AbbVie, Inc., North Chicago, IL, USA.
  • Hu B; AbbVie, Inc., North Chicago, IL, USA.
  • Gifford M; AbbVie, Inc., North Chicago, IL, USA.
  • Barch D; AbbVie, Inc., North Chicago, IL, USA.
  • Roberts-Rapp L; AbbVie, Inc., North Chicago, IL, USA.
  • Ansell PJ; AbbVie, Inc., North Chicago, IL, USA.
  • Xiong H; AbbVie, Inc., North Chicago, IL, USA.
  • Ocampo C; AbbVie, Inc., North Chicago, IL, USA.
  • Tolcher AW; START San Antonio, San Antonio, TX, USA.
Invest New Drugs ; 38(5): 1483-1494, 2020 10.
Article en En | MEDLINE | ID: mdl-32189093
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inmunoconjugados / Anticuerpos Monoclonales Humanizados / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inmunoconjugados / Anticuerpos Monoclonales Humanizados / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article