Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

Müller, Paul M; Rademacher, Juliane; Bagshaw, Richard D; Wortmann, Celina; Barth, Carolin; van Unen, Jakobus; Alp, Keziban M; Giudice, Girolamo; Eccles, Rebecca L; Heinrich, Louise E; Pascual-Vargas, Patricia; Sanchez-Castro, Marta; Brandenburg, Lennart; Mbamalu, Geraldine; Tucholska, Monika; Spatt, Lisa; Czajkowski, Maciej T; Welke, Robert-William; Zhang, Sunqu; Nguyen, Vivian; Rrustemi, Trendelina; Trnka, Philipp; Freitag, Kiara; Larsen, Brett; Popp, Oliver; Mertins, Philipp; Gingras, Anne-Claude; Roth, Frederick P; Colwill, Karen; Bakal, Chris; Pertz, Olivier; Pawson, Tony; Petsalaki, Evangelia; Rocks, Oliver

Müller, Paul M; Rademacher, Juliane; Bagshaw, Richard D; Wortmann, Celina; Barth, Carolin; van Unen, Jakobus; Alp, Keziban M; Giudice, Girolamo; Eccles, Rebecca L; Heinrich, Louise E; Pascual-Vargas, Patricia; Sanchez-Castro, Marta; Brandenburg, Lennart; Mbamalu, Geraldine; Tucholska, Monika; Spatt, Lisa; Czajkowski, Maciej T; Welke, Robert-William; Zhang, Sunqu; Nguyen, Vivian; Rrustemi, Trendelina; Trnka, Philipp; Freitag, Kiara; Larsen, Brett; Popp, Oliver; Mertins, Philipp; Gingras, Anne-Claude; Roth, Frederick P; Colwill, Karen; Bakal, Chris; Pertz, Olivier; Pawson, Tony; Petsalaki, Evangelia; Rocks, Oliver.

Müller PM; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Rademacher J; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Bagshaw RD; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Wortmann C; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Barth C; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
van Unen J; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Alp KM; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Giudice G; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
Eccles RL; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Heinrich LE; Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
Pascual-Vargas P; Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
Sanchez-Castro M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Brandenburg L; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Mbamalu G; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Tucholska M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Spatt L; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Czajkowski MT; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Welke RW; Berlin Institute of Health (BIH), Berlin, Germany.
Zhang S; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Nguyen V; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Rrustemi T; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Trnka P; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Freitag K; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Larsen B; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Popp O; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Mertins P; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Gingras AC; Berlin Institute of Health (BIH), Berlin, Germany.
Roth FP; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Colwill K; Berlin Institute of Health (BIH), Berlin, Germany.
Bakal C; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Pertz O; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Pawson T; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Petsalaki E; Donnelly Centre and Departments of Molecular Genetics and Computer Science, University of Toronto, Toronto, Ontario, Canada.
Rocks O; Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

Nat Cell Biol ; 22(4): 498-511, 2020 04.

Article en En | MEDLINE | ID: mdl-32203420

Asunto(s)

Citoesqueleto/genética; Proteínas Activadoras de GTPasa/genética; Integrinas/genética; Mecanotransducción Celular/genética; Factores de Intercambio de Guanina Nucleótido Rho/genética; Proteína de Unión al GTP rac1/genética; Animales; Células COS; Adhesión Celular; Línea Celular; Movimiento Celular; Chlorocebus aethiops; Biología Computacional; Citoesqueleto/metabolismo; Citoesqueleto/ultraestructura; Perros; Fibroblastos/metabolismo; Fibroblastos/ultraestructura; Proteínas Activadoras de GTPasa/clasificación; Proteínas Activadoras de GTPasa/metabolismo; Perfilación de la Expresión Génica; Regulación de la Expresión Génica; Células HEK293; Células HeLa; Humanos; Integrinas/metabolismo; Células de Riñón Canino Madin Darby; Ratones; Pan troglodytes; Dominios Proteicos; Ratas; Factores de Intercambio de Guanina Nucleótido Rho/clasificación; Factores de Intercambio de Guanina Nucleótido Rho/metabolismo; Proteína de Unión al GTP rac1/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citoesqueleto / Integrinas / Proteína de Unión al GTP rac1 / Proteínas Activadoras de GTPasa / Mecanotransducción Celular / Factores de Intercambio de Guanina Nucleótido Rho Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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