[Pathophysiological Study on Thoracic Ascending Aorta of Mice with Myh11 R247C Heterozygous Mutation in Norepinephrine-induced Hypertension Model].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 51(2): 200-206, 2020 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-32220188
ABSTRACT
OBJEVTIVE To explore the thoracic ascending aortic ï¼TAAï¼ pathophysiological characteristics of heterozygous mutant Myh11 R247C/+ mice under the norepinephrine-induced hypertension mode. METHODS:
Female heterozygous mutant Myh11 R247C/+ and wild type Myh11 +/+ mice were selected as experimental group (HET group) and control group (WT group)ï¼respectively. The hypertensive model was induced by intraperitoneal injection of norepinephrine (NE)ï¼and TAA diameter and invasive blood pressure (Bp) data were collected dynamically in real time using high-frequency ultrasound imaging and invasive arterial blood pressure monitoring techniqueï¼so as to indirectly analyze TAA compliance of two groups of mice. At the same timeï¼the incidences of hemothorax and TAA rupture were further analyzed by autopsy and histology.RESULTS:
After injection of NEï¼heterozygous mice did not show a higher Bp increase percentage in systole or diastole comparing with wildtype mice. Howeverï¼heterozygous mice exhibited 17% and 32% higher TAA diameter dilation percentage than wildtype ones in systole and diastole respectively. Two heterozygous mice had TAA dissection and ruptureï¼and the incidence of hemothorax in heterozygous mice (3/5) was higher than that in wildtype (0/5).CONCLUSION:
It was very likely that the altered TAA wall compliance of mutant Myh11 R247C/+ mice had led to a higher TAA dilation degree than that in wildtypeï¼and even could be the potential reason of TAA dissection and rupture.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aorta Torácica
/
Aneurisma de la Aorta Torácica
/
Aneurisma Roto
/
Cadenas Pesadas de Miosina
/
Hipertensión
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Año:
2020
Tipo del documento:
Article