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Utilization of intravenous or subcutaneous immunoglobulins in secondary immune deficiency (ULTIMATE): A retrospective multicenter study.
Legendre, Paul; Chahwan, Doumit; Marjanovic, Zora; Vignon, Marguerite; Hermine, Olivier; Lortholary, Olivier; Morelle, Guillaume; Darrodes, Marie; Kahn, Jean-Emmanuel; Ouzegdouh, Maya; Chaibi, Pascal; Montestruc, François; Caumont-Prim, Aurore; Le Jouan, Mélisande; Hassani, Yasmine; Godeau, Bertrand; Durand-Zaleski, Isabelle; Mouthon, Luc.
  • Legendre P; Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
  • Chahwan D; Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
  • Marjanovic Z; Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint-Antoine, AP-HP, Paris, France.
  • Vignon M; Service d'Hématologie Clinique, Hôpital Cochin, AP-HP, Paris, France.
  • Hermine O; Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Necker, AP-HP, Paris, France.
  • Lortholary O; Service de Maladies infectieuses et tropicales, Hôpital Necker, AP-HP, Paris, France.
  • Morelle G; Service d'Immuno-hématologie pédiatrique, Hôpital Necker, AP-HP, Paris, France.
  • Darrodes M; Service de pharmacie, Hôpital Foch, Suresnes, France.
  • Kahn JE; Service de Médecine Interne, Hôpital Ambroise Paré, AP-HP, Boulogne, France.
  • Ouzegdouh M; Service d'Hématologie Clinique, Centre hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
  • Chaibi P; Service d'Onco-Hématologie Gériatrique, Hôpital Charles-Foix, AP-HP, Vitry sur Seine, France.
  • Montestruc F; eXYSTAT, Malakoff, France.
  • Caumont-Prim A; eXYSTAT, Malakoff, France.
  • Le Jouan M; Observatoire des Médicaments, des Dispositifs médicaux et de l'Innovation Thérapeutique d'Ile-de-France (OMEDIT IDF), Paris, France.
  • Hassani Y; Observatoire des Médicaments, des Dispositifs médicaux et de l'Innovation Thérapeutique d'Ile-de-France (OMEDIT IDF), Paris, France.
  • Godeau B; Service de Médecine Interne, Hôpital Henri Mondor, AP-HP, Créteil, France.
  • Durand-Zaleski I; Unité de Recherche Clinique en Économie de la Santé d'Île-de-France, Hôpital de l'Hôtel-Dieu, AP-HP, Paris, France.
  • Mouthon L; Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Service de Médecine Interne, Hôpital Henri Mondor, AP-HP, Créteil, France. Electronic address: luc.mouthon@aphp.fr.
Clin Immunol ; 215: 108419, 2020 06.
Article en En | MEDLINE | ID: mdl-32289463
ABSTRACT

INTRODUCTION:

We conducted a retrospective multicenter cohort study of patients receiving Immunoglobulin replacement therapy (IgRT) for secondary immune deficiency (SID) during 2012.

METHODS:

Data were retrospectively collected from the first dose of Ig administered in 2012 to 1 year afterward in terms of the indication for IgRT, as well as efficacy and safety.

RESULTS:

In total, 16 hospitals participated in the study, and 368 patients were included. Indications for IgRT were non-Hodgkin lymphoma (82 [22.3%] patients), multiple myeloma (76 [20.7%]), chronic lymphocytic leukemia (64 [17.4%]) and other (79 [21.5%]). Only 89 (24.2%) patients received IgRT according to 2011 European Medical Agency (EMA) recommendations; 196 (53.3%) received prophylactic antibiotics and 262 (76.2%) had an IgG level < 4 g/L before IgRT initiation.

CONCLUSION:

In this study, whatever the criteria, only 24.2% of patients with SID who received IgRT met EMA recommendations, which suggests a misuse of IgRT in SID.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoglobulinas Intravenosas / Síndromes de Inmunodeficiencia Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoglobulinas Intravenosas / Síndromes de Inmunodeficiencia Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article