Oral application of bulleyaconitine A attenuates morphine tolerance in neuropathic rats by inhibiting long-term potentiation at C-fiber synapses and protein kinase C gamma in spinal dorsal horn.

Mai, Jie-Zhen; Liu, Chong; Huang, Zhuo; Mai, Chun-Lin; Zhou, Xin; Zhang, Jun; Liu, Xian-Guo

Mai, Jie-Zhen; Liu, Chong; Huang, Zhuo; Mai, Chun-Lin; Zhou, Xin; Zhang, Jun; Liu, Xian-Guo.

Mai JZ; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Liu C; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Huang Z; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Mai CL; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zhou X; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zhang J; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Liu XG; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Mol Pain ; 16: 1744806920917242, 2020.

Article en En | MEDLINE | ID: mdl-32290780

Asunto(s)

Aconitina/análogos & derivados; Tolerancia a Medicamentos; Morfina/uso terapéutico; Fibras Nerviosas Amielínicas/metabolismo; Neuroglía/metabolismo; Proteína Quinasa C/metabolismo; Asta Dorsal de la Médula Espinal/metabolismo; Sinapsis/metabolismo; Aconitina/administración & dosificación; Aconitina/uso terapéutico; Aconitum/metabolismo; Administración Oral; Animales; Astrocitos/metabolismo; Conducta Animal; Dolor Crónico; Potenciación a Largo Plazo; Vértebras Lumbares/efectos de los fármacos; Masculino; Microglía/metabolismo; Ratas; Ratas Sprague-Dawley; Médula Espinal/metabolismo; Regulación hacia Arriba

Palabras clave

Bulleyaconitine A; glial cells; long-term potentiation; morphine tolerance; neuropathic pain; protein kinase C gamma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sinapsis / Aconitina / Proteína Quinasa C / Neuroglía / Fibras Nerviosas Amielínicas / Tolerancia a Medicamentos / Asta Dorsal de la Médula Espinal / Morfina Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

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