Choice of first line systemic treatment in pancreatic cancer among national experts.
Pancreatology
; 20(4): 686-690, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32299764
ABSTRACT
BACKGROUND:
Treatment options for patients with metastatic pancreatic cancer depend on various factors, including performance status, tumor burden and patient preferences. Metastatic pancreatic cancer is incurable and many systemic treatment options have been investigated over the past decades. This analysis of patterns of practice was performed to identify decision criteria and their impact on the choice of first-line management of metastatic pancreatic cancer. MATERIALS ANDMETHODS:
Members of the Swiss Group for Clinical Cancer Research (SAKK) Gastrointestinal Cancer Group were contacted and agreed to participate in this analysis. Decision trees for the first line treatment of metastatic pancreatic cancer from 9 centers in Switzerland were collected and analyzed based on the objective consensus methodology to identify consensus and discrepancies in clinical decision-making.RESULTS:
The final treatment algorithms included 3 decision criteria (comorbidities, performance status and age) and 5 treatment options FOLFIRINOX, FOLFOX, gemcitabine + nab-paclitaxel, gemcitabine mono and best supportive care.CONCLUSION:
We identified multiple decision criteria relevant to all participating centers. We found consensus for the treatment of young (age below 65) patients with good performance status with FOLFIRINOX. For patients with increasing age and reducing performance status there was a decreasing trend to use gemcitabine + nab-paclitaxel. Gemcitabine monotherapy was typically offered to patients in the presence of comorbidities. For patients with ECOG 3-4, most of the experts recommended BSC.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Toma de Decisiones Clínicas
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Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article