Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.
Trends Biochem Sci
; 45(5): 367-369, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32311329
ABSTRACT
Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Microscopía por Crioelectrón
Idioma:
En
Año:
2020
Tipo del documento:
Article