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Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages.
Bochkareva, S S; Karaulov, A V; Aleshkin, A V; Novikova, L I; Kiseleva, I A; Rubal'skii, E O; Mekhtiev, E R; Styshnev, A O; Zul'karneev, E R; Anurova, M N; Bakhrushina, E O; Letarov, A V.
  • Bochkareva SS; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Karaulov AV; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Aleshkin AV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Novikova LI; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia. andreialeshkin@googlemail.com.
  • Kiseleva IA; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Rubal'skii EO; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Mekhtiev ER; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Styshnev AO; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Zul'karneev ER; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Anurova MN; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Bakhrushina EO; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Letarov AV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med ; 168(6): 748-752, 2020 Apr.
Article en En | MEDLINE | ID: mdl-32328936
ABSTRACT
Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacteriófagos / ADN Viral / Heces Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacteriófagos / ADN Viral / Heces Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article