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Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes.
Calderon, Gerardo; McRae, Alison; Rievaj, Juraj; Davis, Judith; Zandvakili, Inuk; Linker-Nord, Sara; Burton, Duane; Roberts, Geoffrey; Reimann, Frank; Gedulin, Bronislava; Vella, Adrian; LaRusso, Nicholas F; Camilleri, Michael; Gribble, Fiona M; Acosta, Andres.
  • Calderon G; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • McRae A; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Rievaj J; University of Cambridge, UK; Current affiliation: Dosage Form Design & Development, AstraZeneca Granta Park, Cambridge CB21 6GH, UK.
  • Davis J; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Zandvakili I; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Linker-Nord S; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Burton D; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Roberts G; Current affiliation: Dosage Form Design & Development, AstraZeneca Granta Park, Cambridge CB21 6GH, UK.
  • Reimann F; University of Cambridge, UK.
  • Gedulin B; Satiogen Pharmaceuticals, San Diego, CA, United States.
  • Vella A; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
  • LaRusso NF; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Camilleri M; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States.
  • Gribble FM; University of Cambridge, UK.
  • Acosta A; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton 8-142, 200 First St. S.W., Rochester, MN 55905, United States. Electronic address: acosta.andres@mayo.edu.
EBioMedicine ; 55: 102759, 2020 May.
Article en En | MEDLINE | ID: mdl-32344198
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucemia / Ácidos y Sales Biliares / Colon / Diabetes Mellitus Tipo 2 / Íleon / Obesidad Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucemia / Ácidos y Sales Biliares / Colon / Diabetes Mellitus Tipo 2 / Íleon / Obesidad Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article