Enigmatic MELK: The controversy surrounding its complex role in cancer.

McDonald, Ian M; Graves, Lee M

McDonald, Ian M; Graves, Lee M.

McDonald IM; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
Graves LM; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

J Biol Chem ; 295(24): 8195-8203, 2020 06 12.

Article en En | MEDLINE | ID: mdl-32350113

Asunto(s)

Neoplasias/enzimología; Proteínas Serina-Treonina Quinasas/metabolismo; Animales; Proliferación Celular; Humanos; Modelos Biológicos; Neoplasias/patología

Palabras clave

CRISPR/Cas; OTS167; RNA interference (RNAi); cancer; cell proliferation; drug target; inhibitor; maternal embryonic leucine zipper kinase (MELK); serine/threonine protein kinase; target specificity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Neoplasias Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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