Anti-inflammatory octahydroindolizine alkaloid enantiomers from Dendrobium crepidatum.
Bioorg Chem
; 100: 103809, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32361293
ABSTRACT
Six pairs of octahydroindolizine-type alkaloid enantiomers (1-6) including three new compounds [(-)-1/(+)-1, 2] were isolated from the stems of Dendrobium crepidatum. Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and comparison between the experimental and calculated electronic circular dichroism (ECD). All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells. It was found that compounds (+)-1, 2 and (+)-6 exhibited pronounced inhibition on NO production with IC50 values in the range of 3.62-16.11 µM, being more active than the positive control, dexamethasone (IC50 = 47.04 µM). In vivo, compound 6 (100, 50 and 10 mg/kg) showed protective effects against LPS-induced acute lung injury (ALI) in mice.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dendrobium
/
Alcaloides
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article