Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank.
Br J Cancer
; 123(2): 316-324, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32376888
ABSTRACT
BACKGROUND:
Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both oestrogen receptor-α and -ß, and oestrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating oestradiol is associated with increased ICC risk, further supporting a hormonal aetiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC.METHODS:
We harmonised data from 1,107,498 women who enroled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from the LCPP (n = 180 cases) and the UK Biobank (n = 57 cases).RESULTS:
Hysterectomy was associated with a doubling of ICC risk (HR = 1.98, 95% CI 1.27-3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR = 1.62, 95% CI 1.03-2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors.CONCLUSIONS:
This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Colangiocarcinoma
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Anticonceptivos Hormonales Orales
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Hormonas
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Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Aged
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Female
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Humans
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Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article