Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants.
Clin Infect Dis
; 71(16): 2265-2268, 2020 11 19.
Article
en En
| MEDLINE
| ID: mdl-32382733
ABSTRACT
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-É (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cloroquina
/
Citocinas
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article