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Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Claes, Filip; Rudyak, Stanislav; Laird, Angela S; Louros, Nikolaos; Beerten, Jacinte; Debulpaep, Maja; Michiels, Emiel; van der Kant, Rob; Van Durme, Joost; De Baets, Greet; Houben, Bert; Ramakers, Meine; Yuan, Kristy; Gwee, Serene S L; Hernandez, Sara; Broersen, Kerensa; Oliveberg, Mikael; Moahamed, Barbara; Kirstein, Janine; Robberecht, Wim; Rousseau, Frederic; Schymkowitz, Joost.
  • Claes F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Rudyak S; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Laird AS; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Louros N; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Beerten J; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Leninskiy Prospekt, 14, Moscow 119991, Russia.
  • Debulpaep M; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.
  • Michiels E; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia.
  • van der Kant R; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Van Durme J; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • De Baets G; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Houben B; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.
  • Ramakers M; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Yuan K; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.
  • Gwee SSL; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Hernandez S; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Broersen K; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Oliveberg M; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Moahamed B; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Kirstein J; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Robberecht W; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.
  • Rousseau F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.
  • Schymkowitz J; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
Protein Eng Des Sel ; 32(10): 443-457, 2019 12 31.
Article en En | MEDLINE | ID: mdl-32399571
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ingeniería de Proteínas / Proteínas HSP70 de Choque Térmico / Superóxido Dismutasa-1 / Esclerosis Amiotrófica Lateral / Mutación Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ingeniería de Proteínas / Proteínas HSP70 de Choque Térmico / Superóxido Dismutasa-1 / Esclerosis Amiotrófica Lateral / Mutación Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article