Pathophysiology of Drug-Induced Hypomagnesaemia.
Drug Saf
; 43(9): 867-880, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32399868
ABSTRACT
Magnesium (Mg2+) is the second most abundant intracellular and fourth extracellular cation found in the body and is involved in a wide range of functions in the human cell and human physiology. Its role in most of the enzyme processes (ATP-ases)-stabilisation of nucleic acids (DNA, RNA), regulation of calcium and potassium ion channels, proliferation, glucose metabolism and apoptosis-make it one of the most important cations in the cell. Three pathogenetic mechanisms are mainly implicated in the development of hypomagnesaemia reduced food intake, decreased intestinal absorption and increased renal excretion of Mg2+. This review presents the function of Mg2+, how it is handled in the kidney and the drugs that cause hypomagnesaemia. The frequency and the number of drugs like diuretics and proton-pump inhibitors (PPIs) that are used daily in medical practice are discussed in order to prevent and treat adverse effects by providing an insight into Mg2+ homeostasis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diuréticos
/
Inhibidores de la Bomba de Protones
/
Deficiencia de Magnesio
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article