Divergent syntheses of okaramines C, J, L, and S-U.
Org Biomol Chem
; 18(20): 3848-3852, 2020 05 27.
Article
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| MEDLINE
| ID: mdl-32400817
ABSTRACT
The total synthesis of six novel okaramines (C, J, L, and S-U) was accomplished with a precise synthesis scheme involving a few steps and a practical yield of 6.7%-23% was obtained. The significance of this study includes the design of a successful and convenient synthesis method for preparation of 3a-hydroxy-pyrrolo[2,3-b]-indole and C-7 prenylated l-tryptophan derivatives using a nucleophilic attack of cyclopropylazetoindoline and an aza-Claisen rearrangement of N-reverse-prenyl tryptophan, respectively.
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2020
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Article