An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum.
Science
; 368(6492): 754-759, 2020 05 15.
Article
en En
| MEDLINE
| ID: mdl-32409472
ABSTRACT
The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from red blood cells, which triggers 48-hour fever cycles in the host. This cycle could be driven extrinsically by host circadian processes or by a parasite-intrinsic oscillator. To distinguish between these hypotheses, we examine the P. falciparum cycle in an in vitro culture system and show that the parasite has molecular signatures associated with circadian and cell cycle oscillators. Each of the four strains examined has a different period, which indicates strain-intrinsic period control. Finally, we demonstrate that parasites have low cell-to-cell variance in cycle period, on par with a circadian oscillator. We conclude that an intrinsic oscillator maintains Plasmodium's rhythmic life cycle.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
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Malaria Falciparum
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Eritrocitos
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Relojes Circadianos
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Interacciones Huésped-Parásitos
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Estadios del Ciclo de Vida
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article